When we think of dementia, we usually imagine older people losing their memory. But two new studies suggest that feeling depressed or having mood changes in your 40s or 50s might actually be an early warning sign of dementia.
 What the Research Says:
Study 1: Depression Increases Dementia Risk at Any Age
A study published in eClinicalMedicine found that depression at any point in life—whether in your 30s, 40s, or even later—can increase your chances of developing dementia.
Researchers from universities in the UK and Australia, including the University of Nottingham and Curtin University, led this study.
Lead researcher Jacob Brain explained that depression in later life could even be an early symptom of dementia, not just a risk factor. They studied how the timing of depression—whether it happened in midlife or later—impacted dementia risk.
Study 2: Mood Changes After 40 Might Signal Brain Changes
Another study from Japan’s National Institute of Quantum Science and Technology found that people over 40 who experience depression or bipolar disorder may be twice as likely to develop brain diseases like dementia.
The researchers looked at changes in the brain and found that people with symptoms like hallucinations or delusions had more abnormal tau protein in their brains. This protein is linked to diseases like Alzheimer’s.
Why This Is Important
Dementia affects over 57 million people worldwide. In India alone, about 8.8 million older adults are living with it.
At the same time, depression is also a serious problem in India. A government survey showed that about 15% of Indian adults need mental health care, especially for depression.
The COVID-19 pandemic made things worse, and many people are still struggling emotionally. These studies show that mental health problems like depression may also raise your chances of getting dementia.
 What You Can Do:
If you’re over 40 and feel sad, irritable, or have mood swings often, don’t ignore it. It could be more than just stress—it might be your brain telling you something important.
Experts suggest:
- Get mental health help early — don’t wait
- Keep your brain active by learning new things and staying social
- Live a healthy lifestyle: exercise, eat well, sleep enough, and manage stress
 Final Thought
We often think mental and brain health are separate. But these new studies show that your mood could be one of the first signs your brain is in trouble. So, if something feels off emotionally, listen to your body — it could help protect your brain for the future.
Note: This article is for information only and is not a substitute for medical advice. Please consult a doctor for proper diagnosis and treatment.
Â
